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KMID : 0861020080230040103
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Korea Journal of Herbology
2008 Volume.23 No. 4 p.103 ~ p.112
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Anti-diabetic Effect of Indongdeungjikolpi-tang in Streptozotocin-induced Diabetic Rats
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Bae Hyo-Sang
Park Seong-Sik
Jung Jin-Ki
Yoon Cheol-Ho
Byun Sang-Hyuk
Park Yong-Ki
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Abstract
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Objectives: Indongdeungjikolpi-tang(IJT) is used as a traditional treatment of diabetes in oriental clinincs. This study aimed to evaluate the anti-diabetic effect of Indongdeungjikolpi-tang(IJT) in streptozotocin(STZ)-induced diabetic rats.
Methods: Diabetes was induced by intraperitoneal injection of streptozotocin(STZ; 60 mg/kg BW) to Sprague-Dawley male rats. Experimental animals(six per group), were treated by oral administration of IJT(100 and 500 mg/kg BW) and glibendimide(3 mg/kg), a known antidiabetic drug for comparison, during 4 weeks. We measured the levels of glucose, insuline, triglyceride, creatinine and urea in sera of each group. An oral glucose tolerance test(OGTT) was also performed in all groups.
Results: IJT(100 and 500 mg/kg) significantly reduced blood glucose levels and increased plasma insulin levels in STZ-induced diabetic rats. IJT also significantly reduced the plasma levels of tryglyceride, creatinine and urea in STZ-induced diabetic rats. The OGTT results showed a significant improvement in glucose tolerance in IJT-administrated rats.
Conclusions: These data indicate that IJT may improve glocose homeostasis in STZ-induced diabetes, which could be associated with stimulation of insulin secretion.
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KEYWORD
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Indongdeungjikolpi-tang, streptozotocin, diabetes, anti-diabetic effect
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